Propagation of Elastic Waves in Homogeneous Media: 2D Numerical Simulation for a Concrete Specimen

This paper addresses the theoretical foundation of a localization method for crack detection in a concrete sample based on the time of arrival of the elastic wave generated by the crack formation to a group of sensors positioned on the boundary of the sample. The equations of motion for the elastic waves are carefully presented, including a body force term which accounts for the sudden formation of a crack. Then, a localization method based on the detection of acoustic emissions, and specifically on their arrival times, is described. Finally, a discretization scheme for the 2D equations of elasticity is developed, and some numerical experiments are performed to assess the validity of the method

The development and application of an optimization tool in industrial design

AbstractDesigners are identified, in industry 4.0, as the professional figures that have to design well performing new object. In order to do this, it is necessary to take into account a series of properties called design objectives. Often the structural problem of new design is underestimated or even not considered. This can be a real problem because this objective is in competitive and in contrast with other design objectives. So, this can bring to substantial change in a design in the final phase and sometimes to the complete change. In this paper is presented an optimization workflow that adopt a Multi Objective Optimization engine so called "Octopus" and Karamba3D, that is a Finite Elements (FE) plug-in, typically used in structural simulations, these extensions run in a software: Grassopper3D, that is a parametric design tool. The workflow allows designers to explore a large range of solutions and at the same time permits to filter and sort the optimized models in order to analyze the tradeoff of the resultant solution space, both qualitatively and quantitatively. In such way designers can obtain easily a lot of information of the generate design and identify potential solution for immediate use or for further optimization. In this paper is analyzed a design problem of an ergonomic chair in order to provide the efficiency of the workflow. The design criteria and the structural problem for this type of design object are identified as the main optimization objectives in order to iteratively improve the design solutions

A social robot connected with chatGPT to improve cognitive functioning in ASD subjects

Neurodevelopmental Disorders (NDDs) represent a significant healthcare and economic burden for families and society. Technology, including AI and digital technologies, offers potential solutions for the assessment, monitoring, and treatment of NDDs. However, further research is needed to determine the effectiveness, feasibility, and acceptability of these technologies in NDDs, and to address the challenges associated with their implementation. In this work, we present the application of social robotics using a Pepper robot connected to the OpenAI system (Chat-GPT) for real-time dialogue initiation with the robot. After describing the general architecture of the system, we present two possible simulated interaction scenarios of a subject with Autism Spectrum Disorder in two different situations. Limitations and future implementations are also provided to provide an overview of the potential developments of interconnected systems that could greatly contribute to technological advancements for Neurodevelopmental Disorders (NDD)

Nano‐/microfiber scaffold for tissue engineering: Physical and biological properties

Alginate hydrogel (AH) has intrinsic physical and biological limitations that hinder its broader application in tissue engineering. We hypothesized that the inclusion of nanofibers in the hydrogel and the use of a biotemplate that mimics nature would enhance the translational potential of alginate hydrogels. In this study, we have shown a method to obtain nano‐/microfibers of titanium (nfTD) and hydroxyapatite (nfHY) using cotton as a biotemplate. These fibers were incorporated in the alginate hydrogel and the mechanical characteristics and biological response to these reinforced materials were evaluated. We observed that these nanofibers resembled the structure of natural collagen and did not mediate cell toxicity. The incorporation of nfTD or nfHY to the AH has not increased the viscosity of the hydrogel. Therefore, this is a feasible method to produce a scaffold with improved physical characteristics, while at the same time generating an enhanced environment for cell adhesion and proliferation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3051–3058, 2012.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93772/1/34242_ftp.pd

X-shooter Spectroscopy and HST Imaging of 15 Massive Quiescent Galaxies at z ≳ 2

We present a detailed analysis of a large sample of spectroscopically confirmed massive quiescent galaxies (MQGs; log(M*/M ⊙) ~ 11.5) at z ≳ 2. This sample comprises 15 galaxies selected in the COSMOS and UDS fields by their bright K-band magnitudes and followed up with Very Large Telescope (VLT) X-shooter spectroscopy and Hubble Space Telescope (HST)/WFC3 H_(F160W) imaging. These observations allow us to unambiguously confirm their redshifts, ascertain their quiescent nature and stellar ages, and reliably assess their internal kinematics and effective radii. We find that these galaxies are compact, consistent with the high-mass end of the stellar mass–size relation for quiescent galaxies at z = 2. Moreover, the distribution of the measured stellar velocity dispersions of the sample is consistent with the most massive local early-type galaxies from the MASSIVE Survey, showing that evolution in these galaxies is dominated by changes in size. The HST images reveal, as surprisingly high, that 40% of the sample has tidal features suggestive of mergers and companions in close proximity, including three galaxies experiencing ongoing major mergers. The absence of velocity dispersion evolution from z = 2 to 0, coupled with a doubling of the stellar mass, with a factor of 4 size increase and the observed disturbed stellar morphologies, supports dry minor mergers as the primary drivers of the evolution of the MQGs over the last 10 billion yr

Early-type galaxies at z = 1.3. I. The Lynx supercluster: cluster and groups at z=1.3. Morphology and color-magnitude relation

We confirm the detection of 3 groups in the Lynx supercluster, at z~1.3, and give their redshifts and masses. We study the properties of the group galaxies as compared to the central clusters, RXJ0849+4452 and RXJ0848+4453, selecting 89 galaxies in the clusters and 74 galaxies in the groups. We morphologically classify galaxies by visual inspection, noting that our early-type galaxy (ETG) sample would have been contaminated at the 30% -40% level by simple automated classification methods (e.g. based on Sersic index). In luminosity selected samples, both clusters and groups show high fractions of Sa galaxies. The ETG fractions never rise above ~50% in the clusters, which is low compared to the fractions observed in clusters at z~1. However, ETG plus Sa fractions are similar to those observed for ETGs in clusters at z~1. Bulge-dominated galaxies visually classified as Sas might also be ETGs with tidal features or merger remnants. They are mainly red and passive, and span a large range in luminosity. Their star formation seems to have been quenched before experiencing a morphological transformation. Because their fraction is smaller at lower redshifts, they might be the spiral population that evolves into ETGs. For mass-selected samples, the ETG fraction show no significant evolution with respect to local clusters, suggesting that morphological transformations occur at lower masses and densities. The ETG mass-size relation shows evolution towards smaller sizes at higher redshift in both clusters and groups, while the late-type mass-size relation matches that observed locally. The group ETG red sequence shows lower zero points and larger scatters than in clusters, both expected to be an indication of a younger galaxy population. The estimated age difference is small when compared to the difference in age at different galaxy masses.Comment: ApJ, submitted - referee report answered - iterating with the refere

Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis

Importance: Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized by age of symptom onset less than 25 years and a variable presentation.Objective: To identify the genetic variants associated with juvenile ALS.Design, Setting, and Participants: In this multicenter family-based genetic study, trio whole-exome sequencing was performed to identify the disease-associated gene in a case series of unrelated patients diagnosed with juvenile ALS and severe growth retardation. The patients and their family members were enrolled at academic hospitals and a government research facility between March 1, 2016, and March 13, 2020, and were observed until October 1, 2020. Whole-exome sequencing was also performed in a series of patients with juvenile ALS. A total of 66 patients with juvenile ALS and 6258 adult patients with ALS participated in the study. Patients were selected for the study based on their diagnosis, and all eligible participants were enrolled in the study. None of the participants had a family history of neurological disorders, suggesting de novo variants as the underlying genetic mechanism.Main Outcomes and Measures: De novo variants present only in the index case and not in unaffected family members.Results: Trio whole-exome sequencing was performed in 3 patients diagnosed with juvenile ALS and their parents. An additional 63 patients with juvenile ALS and 6258 adult patients with ALS were subsequently screened for variants in the SPTLC1 gene. De novo variants in SPTLC1 (p.Ala20Ser in 2 patients and p.Ser331Tyr in 1 patient) were identified in 3 unrelated patients diagnosed with juvenile ALS and failure to thrive. A fourth variant (p.Leu39del) was identified in a patient with juvenile ALS where parental DNA was unavailable. Variants in this gene have been previously shown to be associated with autosomal-dominant hereditary sensory autonomic neuropathy, type 1A, by disrupting an essential enzyme complex in the sphingolipid synthesis pathway.Conclusions and Relevance: These data broaden the phenotype associated with SPTLC1 and suggest that patients presenting with juvenile ALS should be screened for variants in this gene.</p

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Measurement of the correlation between the polar angles of leptons from top quark decays in the helicity basis at √s = 7 TeV using the ATLAS detector

A measurement of the correlations between the polar angles of leptons from the decay of pair-produced t and t̄ quarks in the helicity basis is reported, using proton-proton collision data collected by the ATLAS detector at the LHC. The dataset corresponds to an integrated luminosity of 4.6  fb−¹ at a center-of-mass energy of √s = 7  TeV collected during 2011. Candidate events are selected in the dilepton topology with large missing transverse momentum and at least two jets. The angles θ1 and θ2 between the charged leptons and the direction of motion of the parent quarks in the tt̄ rest frame are sensitive to the spin information, and the distribution of cosθ1 ⋅ cosθ2 is sensitive to the spin correlation between the t and t̄ quarks. The distribution is unfolded to parton level and compared to the next-to-leading order prediction. A good agreement is observed

Search for massive, long-lived particles using multitrack displaced vertices or displaced lepton pairs in pp collisions at √s = 8 TeV with the ATLAS detector

Many extensions of the Standard Model posit the existence of heavy particles with long lifetimes. This article presents the results of a search for events containing at least one long-lived particle that decays at a significant distance from its production point into two leptons or into five or more charged particles. This analysis uses a data sample of proton-proton collisions at √s=8  TeV corresponding to an integrated luminosity of 20.3  fb−1 collected in 2012 by the ATLAS detector operating at the Large Hadron Collider. No events are observed in any of the signal regions, and limits are set on model parameters within supersymmetric scenarios involving R-parity violation, split supersymmetry, and gauge mediation. In some of the search channels, the trigger and search strategy are based only on the decay products of individual long-lived particles, irrespective of the rest of the event. In these cases, the provided limits can easily be reinterpreted in different scenarios